A New Era in Male Sexual Health

Male Sexual Health: A Global Challenge

  • Worldwide about 100 million men are estimated to suffer from Male Sexual Dysfunction.
  • Erectile dysfunction (ED) and premature ejaculation (PE) are the two most prevalent male sexual dysfunctions.
  • 52% of men aged 40-70 years report some degree of erectile difficulty.
  • The Global Study of Sexual Attitudes and Behaviors and other sources suggests a global prevalence of PE of approximately 20-30% across all age groups.

Unmet Need

  • Despite the advent of Sildenafil being largely successful in erectile dysfunction (ED), its safety concerns continue to fuel the research drive in sexual medicine.
  • Currently used attempts to treat premature ejaculation with counseling sessions or other behavioral therapies have had only limited success. No safe and clinically approved modalities are available for the treatment of premature ejaculation.

Ideal Ingredient for your Male Sexual Health Formulas

HeezOn® is a USA patented all natural, safe and effective blend of ingredients to prolong time to ejaculation, quality of orgasm along with better erections.

HeezOn® works on male sexual health by

  • Enhancing nitric oxide release resulting in better control over secretary activity. Nitric oxide also signals smooth muscle to relax, resulting in vasodilation & increasing blood flow to penis.
  • Increased dopaminergic activity enhances the readiness of motor system to respond to sexual stimuli.

Clinically Tested, All Natural Support for Premature Ejaculation and associated Erectile Dysfunction

Understanding How HeezOn® Works

HeezOn®: Clinically tested, all-natural support for Premature Ejaculation

Pathways on which HeezOn® works

  • Nitric Oxide pathway
  • Antioxidant pathway
  • Anxiolytic pathway
  • Dopaminergic pathway
  • Nutritional pathway

Nitric Oxide Pathway

HeezOn® enhances Nitric Oxide release

Nitric Oxide is involved in the control of secretory activity of the seminal vesicles and prostate

Elevation of extracellular nitric oxide accelerates dopamine release and reduces anxiety/ depression associated with PE

Nitric oxide is also involved in smooth muscle function of seminal vesicles

Enhancement in both these functions (better control on secretory activity and improvement in smooth muscle function) leads to improvement in Premature Ejaculation symptoms

The endothelium of blood vessels also uses nitric oxide to signal the smooth muscle to relax, thus resulting in vasodilation & increasing blood flow to penis. This improve onset and duration of erection

Anxiolytic pathway

Antioxidant activity help to reduce oxidative stress associated with PE & ED
Anxiolytic activity due to decrease in Norepinephrine and serotonin levels and increase in Gamma-amino-butyric acid (GABA) level
Reduce anxiety/ depression associated with premature ejaculation and erectile dysfunction

Dopaminergic Pathway

  • Presence of L-dopa in the formulation up regulates dopaminergic activity.
  • Dopamine reduces anxiety associated with PE
  • Increased dopaminergic activity in the nigrostriatal system of brain enhances the readiness of motor system to respond to sexual stimuli
  • Increased dopaminergic activity in the mesolimbic system of brain is important for the motivation and reinforcement
  • Increased dopaminergic activity in the medial preoptic area is important for genital reflex, motor pattern of copulation and possibly sexual motivation.
  • Dopamine also reduces anxiety associated with ED

Summary

All Natural. Clinically Proven. Patent-pending

Benefits

  • Proven benefits across male adult age group
  • Visible results in 3-4 weeks
  • Non hormonal, non spiked
  • The recent news states that the FDA is going to review testosterone products for their safety again, due to the recent reports that indicate an increased risk of stroke, heart failure in men who are on these therapies. Although, natural testosterone boosters are considered to be fairly safe, one must not ignore the possible risks mentioned above.
  • HeezOn® improves male sexual health without increasing testosterone

1000 mg a day = 64% improvement in premature ejaculation

HEEZON® ADVANTAGES for “Male sexual Dysfunction(MSD)”

SIMPLIFIES THE SUPPORT for MSD which is a complex problem involving varying degrees of Erecticle Dysfunction (ED) accompanied by Premature Ejaculation (PE) and low sexual desire. Hence there is need for an option which simplifies the successful management of multiple aspects of MSD.

Reduces associated anxiety which helps to support healthy sex life

WELL SUITED FOR PEOPLE TAKING NITRATES OR ALPHA BLOCKER DRUGS where Sildanefil is contraindicated. There was no change in electrocardiogram (ECG) seen in subjects during HEEZON® clinical study.

HEEZON® clinical trial also shows evidence to prove “Partner Satisfaction” which is not found with other ingredients for male sexual health

STARTS SHOWING RESULTS in 15 days.

11650 DATA POINTS were captured in HEEZON® clinical trial which comprehensively proved benefits of HEEZON® with no serious adverse effects.

HEEZON® is a VEGAN & NON-GMO and Prop 65 compliant.

HEEZON® clinical trial is significantly superior to trials of other male sexual health ingredients like Korean Ginseng, Yohimbine, Testofen etc due to larger study population, highly validated IIEF & IPE scales used, adverse effects extensively monitored and intention to treat (ITT) way used for analyzing data which removes “bias”.

Regulatory status

Country

Regulatory status

USA

US FDA dietary supplement compliant ingredients

Canada

NPN received, launched in May 2014

Colombia

Registration ongoing

Malaysia

Registration ongoing

Mauritius

Launched in May 2013

Sri Lanka

Launched in Aug 2013

Labeling Recommendation

HeezOn® is proprietary blend containing extracts derived from Tribulus terrestris, Withania somnifera, Asparagus adscendens, Mucuna pruriens, Asteracantha longifolia, Curculigo orchioides, Asphaltum

Brands containing HeezOn®

Clinical Trial Design

  • Phase IIa Study
  • Double blind, placebo controlled Multicenter clinical Trial
  • ICH – GCP compliant trial
  • Registered with Clinical Trial Registry of India
  • Approved by Independent Ethics Committee
  • Total number of subjects = 148
  • Treatment Duration = 60 days
  • Efficacy Parameters = IIEF-A, IIEF B, IPE, EDITS

Research paper published in American Journal of Therapeutics, 2011 Mar-Apr;18(2):162-9

Clinical EFFICACY EVIDENCE

Significant Improvement in Erectile dysfunction

67% upturn in IIEF-A score as against 26% improvement in placebo

Significant Improvement in Premature Ejaculation (PE)

64% improvement in index of PE against 25% improvement in subjects taking placebo

Clinical EFFICACY EVIDENCE

Significant Improvement in Overall Sexual Function

48% increase in IIEF-B scores for the subjects affected predominantly by low libido as against 21% improvement in placebo

Male Satisfaction

78% Improvement in self satisfaction index as compared to 54% with subjects taking placebo

Partner Satisfaction

77% Improvement in partner satisfaction index as compared to 61% with subjects taking placebo

Ingredient facts

Brand Name

HeezOn®

Description

Proprietary blend of standardized herbal extracts

Appearance

Free flowing brown powder

GMO status

Non GMO

Shelf Life

3 years

Suitable to be used in

Supplements in capsules / Tablets dosage form

can be a stand-alone supplement or be added to other actives

Recommended dose

1000mg / day at bedtime

Safety

No side effects have been reported in the clinical studies

No risks have been identified in the usual toxicological studies

Quality

HPTLC fingerprint of HeezOn® ensures same profile of actives as used in clinical trials. HeezOn® confirms to current International standards for allergen, heavy metals, microbial limits.

The Food and Drug Administration has not evaluated statements on this website. The products are not intended to diagnose, treat, cure or prevent disease. This website’s technical content and claims are for business information purposes only. Your legal counsel should review them before use in marketing materials, including product labels. Some of these statements may not apply to your markets or regulations since they are intended for various geographies worldwide.

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