Advanced Liposomal Glutathione

LipoCrystal

 The next generation Glutathione technology

Benefits of LipoCrystal Glutathione

Depigmentation

LipoCrystal Glutathione is known for its depigmentation nature. It helps to lighten our skin cells and provides a youthful glow. Liposomal Glutathione works from within without exposing your skin to hazardous chemicals or other compounds. LipoCrystal liposomal Glutathione can reduce the appearance of dark spots

High Penetration

LipoCrystal, unlike regular Glutathione, can penetrate more effectively and reach lower skin layers where melanin is produced. Once their liposomes release the trapped Glutathione, it becomes available for action.

Protection:

LipoCrystal Glutathione is an efficient antioxidant. It quickly undergoes oxidation, forming a bulkier oxidised glutathione. Once oxidised, glutathione penetration is more challenging and oxidised Glutathione has less efficacy than the reduced Glutathione. The liposomal structure protects Glutathione from oxidation, thereby preserving its effectiveness. 

What are liposomal delivery systems?

The Problem

The absorption and bio-availabilty of supplements is a problem that manufacturers and researchers in the field wrestle with. Excipients, binders, fillers and flow agents can contribute to  poor disintegration rates for tablets and capsules which means poor absorption at best. The next problem is to ensure that the active ingredients moves into the blood stream and reaches the cells.

The Solution

Liposomes have long been used as an effective pharmaceutical delivery method. The liposome delivery method is becoming more common in natural health products. The active ingredients are enveloped in a bubble of phospholipids, fat molecules that comprise the cell wall's central part. This protects the active ingredients and allows them to survive the digestive process better and enter the intestines. The liposome fuses with the cell walls, releasing the active ingredients and entering the bloodstream. The phospholipids of the liposome are then used in the body as they are identical to the cell membrane phospholipids.

Why opt for LipoCrystal?

Glutathione is a tripeptide2 produced by the body composed of the amino acids cystein, glycin, and glutamic acid. Glutathione appears in virtually all cells at high concentrations and is one of the primary antioxidants in the body. Glutathione is a vital tripeptide that has been the subject of several studies. Due to modern living with all the toxic and harmful substances that we are exposed to on a daily basis we require considerable amounts of glutathione. These external factors deplete the stores of glutathione in the body.

Liposomal glutathione is a proven method for delivering the reduced form of glutathione directly to the bloodstream. The liposomes ensure the glutathione is not damaged and reaches the bloodstream quickly. Studies have shown that liposomal glutathione taken orally elevated the store of glutathione.

Skin Whitening

L-Glutathione is one of the most powerful antioxidants in our body. This is gaining traction in terms of skin whitening treatment and achieve the desired pigmentation. With very less to no side-effect, Glutathione skin whitening is by far the most chosen whitening treatment. It is tropically administered orally or topically.

Producing the NEXT GENERATION of LIPOSOMES

Unprecedented high bioavailability

Liposomes for vitamins have been on the market since 2004. There are liquid liposomal products and powdered forms, which are encapsulated.

Over the years, various production methods have evolved. IVN™ uses the most advanced production method of liposomal products in powder form. This production method has its origin in nature. There is no use made of heat, high pressure, or chemicals during the production process, which is common in other production processes. This means the liposomal products are 100% natural and are just about wholly absorbed into the body.

Glutathione (GSH)

  • Glutathione (GSH) is a peptide comprised of the amino acids glutamine, cysteine and glycine.
  • In its reduced form, glutathione serves as a powerful antioxidant.
  • GSH can make DNA, the building blocks of proteins and cells
  • It supports immune function
  • GSH can form sperm cells
  • It is a potent antioxidant and breaks down free radicals
  • It helps specific enzyme function
  • It participates in regenerating vitamins C and E
  • GSH helps transport mercury out of the brain
  • It helps the liver and gallbladder deal with fats
  • GSH assists in regular cell death (a process known as apoptosis)

Glutathione Bioavailability Challenges

  • Orally administered Glutathione is only sparingly absorbed due to its rapid hydrolysis by γ- glutamyltransferase in intestinal mucosa, hepatocytes and cholangiocytes.
  • Many delivery systems, including liposomal delivery systems, have been implemented, optimized and successfully applied as delivery vehicles for GSH.
  • With Glutathione loaded into its core, the liposomal structure enhances bioavailability by protecting the peptide from degradation and transporting it across membranes
  • Nevertheless, conventional liposomal formulations have many drawbacks that affect the therapeutic effect of active biomolecules and are liable to fast ‘clearance’ from the bloodstream.
  • In the same way, phospholipids might also undergo aggregation or flocculation and fusion or coalescence, modifying the vesicle size, initiating the drug seepage, or harming the encapsulated biomolecules.
  • So, Encapsulating biomolecules like Glutathione with liposomes and using fruit fibers is a novel proprietary strategy known as bio-cellular activation to enhance the stability of liposomes via the reinforcement of fibers with lecithin. On that aspect, Lab Biopharma developed a unique technology called ‘Bio Cellular Activated”(BCA) technology, which converts the liquid liposomes to a novel stabilized form of powdered liposomes.

What is Bio Cellular Activated?

LAB Biopharma’s unique Liposomal Technology produces stabilized forms of powdered liposomes integrated with fruit fiber for structural encapsulation of active ingredients

Bio Cellular Activation Technology reduces degradation caused by stomach acids, enables a sustained release of glutathione active into the digestive tract, & enhances absorption for much higher bioavailability of the active ingredient. 

Why Bio Cellular Activated?

Liposomes for Nutrient Delivery

  • Maintaining the stability of active ingredients, like in the case of Glutathione, is challenging. Due to the sensitivity to pH changes, the oral delivery route requires better stability of the ingredients in the gastrointestinal tract.
  • Reduction in the rate of degradation of the active ingredient in the gut facilitation of its absorption can occur by its association with a hydrophilic–hydrophobic interface.
  • Liposomes are an excellent system for delivering problematic active compounds into the body. Hence, the strategy of encapsulating active ingredients in liposomes is adopted through our BCA technology.

Enhanced Stability of Liposomes

  • Conventional liposomal products available in the market are in liquid or paste form. These lack stability; liposomes break very easily in liquid formulations.
  • The powder form is an alternate, better solution, but in the conversion process, the liposome’s core structure may be destroyed due to the evaporation of water. To overcome this, soluble fiber from fruits (apples) are utilized in LipoCrystal to retain the assembly of the liposomal bilayer in its powder form. This helps to encapsulate the bioactive molecules effectively.

Why LipoCrystal powered by BCA?

Sustained Release of Active Ingredients

  • Conventional liposomal formulations have many drawbacks, affecting the therapeutic effect of active biomolecules & are liable to fast ‘clearance’ from the bloodstream.
  • Gradual release of the active ingredients in the gastrointestinal tract enhances absorption & improves the therapeutic efficiency of active ingredients.
  • The fruit-based (apple) fibers are well integrated with liposomes & maintain the spherical core structure even in the powder form, reducing degradation & ensuring a sustained release of active ingredients.

BCA Advantages

Enhanced Stability

Secures the potency of nutrients, ensuring longevity.

Optimized Bioavailability

Ideal harmony of water & fat-loving properties ensures nutrient availability.

Sustained Release

Gradual release of nutrients provides lasting benefits.

Advantages of our proprietary Bio Cellular activated technology

Fruit Fiber

High surface area
Used at very low levels while providing high functional benefits
Non-synthetic, plant- based fiber

Sunflower Lecithin

A safer alternative to soy lecithin
A surfactant that maintains the balance between hydrophilicity & lipophilicity

Lipophilic & Hydrophilic ends of Fruit Fibers

BCA can cross over the gut wall easily
Bind well with lecithin, making a strong reinforcement

Soluble & Insoluble fibers

Contribute as prebiotics
Improves immunomodulatory responses

Liposomes

Higher efficacy & bioavailability of LipoCrystal leads to lower dosage, in-turn reduces side effects

Benefits of LipoCrystal Glutathione

Liposomes for Nutrient Delivery

Study shows that oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function Abstract (from Pub Med)

Background/objectives

Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues for GSH levels may be an important strategy for the prevention of oxidative stress-related diseases. We investigated if oral administration of liposomal GSH is effective at enhancing GSH levels in vivo.

Subjects/methods: 

A 1-month pilot clinical study of oral liposomal GSH administration at two doses (500 and 1000 mg of GSH per day) was conducted in healthy adults. GSH levels in whole blood, erythrocytes, plasma and peripheral blood mononuclear cells (PBMCs) were assessed in 12 subjects at the baseline and after 1, 2 and 4 weeks of GSH administration.

LipoCrystal Glutathione

Manufactured with pure ingredients; no fillers, preservatives, or other non-active ingredients.

The powder has a neutral flavour. No flavour enhancers needed

Long shelf life

High bio-availability - bioavailability studies scheduled first quarter of 2024

Natural production method

Guaranteed high-quality proprietary liposomal products

LipoCrystal for Cosmetics

  • Formation of phospholipid -fiber film with GSH on the skin surface that results in moisturization & skin hydration
  • Liposomes enhance GSH penetration through vesicle adsorption and/or fusion onto the skin surface, & by the interaction of the lipid of liposomes with the stratum corneum
  • LipoCrystal powered by BCA GSH systems become a useful tool for effective sun protection and UV-blocking effects are dependent  on lipid composition
  • Liposomal formulations are more effective in reducing pigmentation
  • Ensures sustained release & protection of GSH

LipoCrystal powered by BCA technology

Glutathione 40%

  • Glutathione, is one of the key vitamins utilized for several uses in pharmaceutical industries.
  • An essential vitamin & a  potential antioxidant  that protects our cells against the effects of free radical
  • This essential nutrient helps shield our cells from the damaging effects of free radicals and is necessary for overall health.

So, an innovative technology by LAB Biopharma has developed to increase the bioavailability of active ingredients natural through new approach, i.e., Bio Cellular Activated (BCA) Technology which helps to increase the bioavailability of the active ingredients!!

Lab Biopharma LipoCrystal Glutathione:

Evidence from SEM of LipoCrystal

  • Conventional GSH appears agglomerated & non-spherical.
  • LipoCrystal displays a smooth surface of the liposomal powder with adequate encapsulation.
  • The creation of a stable liposomal product is demonstrated by the highly orientated, circular,
  • liposomal moiety in the SEM pictures that still contains the active component.

In vitro Studies of Bio Cellular Activated Liposomal ingredient

The in vitro release study and simulated fluid studies show the sustained release and high stability of BCA technology. This can be extended to LipoCrystal that is powered by BCA.

This suggests that Lab Biopharma`s BCA liposomal encapsulation inhibited the release of Vitamin C, which is favorable for prolonged release applications.

This indicates better stability of Lab Biopharma`s Bio Cellular activated Vitamin C in the stomach, therefore, better release & absorption in the gastrointestinal tract.

Stability of LipoCrystal in Skin Care Cream

The stability of the LipoCrystal is very good as it is highly stable in cosmetic creams. The results are given below:

Conclusion

  • LipoCrystal delivers highly pure, reduced glutathione, representing a considerable step forward in nutraceutical delivery methods.
  • LipoCrystal offers an advanced option suitable for many oral and cosmetic applications by providing robust support for antioxidant protection, skin whitening and detoxification.
  • The advanced procedure for the preparation and storage stability of the LipoCrystal provides convenience and makes product commercialization possible.
  • BCA increases site-specific drug targeting to inflamed tissues by utilizing the disease state, including enhanced permeability or changes in pH of inflamed tissues.; thereby allowing for maximum drug action with fewer adverse effects than traditional drug therapy.
  • Collectively, these preliminary findings support the effectiveness of LipoCrystal administration in the immune function and levels of oxidative stress by using it in cosmetic applications.