Super NootrOpa

Wild harvested

Super NootrOpa is the subject of 16 published scientific studies confirming efficacy.

What is Super NootrOPa?

Super NootrOpa is a patented, clinically proven natural botanical nootropic ingredient that improves memory, concentration and learning ability. This ingredient is developed through 50 years of extensive research.

Super NootrOpa is the only clinically proven natural botanical ingredient to improve memory, attention, and focus in adults and children. Gold-standard scientific research has established the clinical efficacies of Super NootrOpa.

Researched Benefits

The Nootropic benefits of Super NootrOpa are demonstrated by 16 published scientific papers consisting of nine randomized human clinical studies, six pre-clinical studies and one meta-analysis conducted across age groups ranging from 06 to 65 years. A single dose of Super NootrOpa, either 320 mg or 640 mg, improves multi-tasking, visual attention, mood, and stress reduction compared to a placebo.

Super NootrOpa quickly improved the speed of continuous performance and visual information processing, reducing stress and mental fatigue just after 2 hours of supplementation.

Super NootrOpa at 125mg/day significantly improved cognitive control, logical memory, working memory, and paired associated learning.

Super NootrOpa improved accuracy, reaction time, problem-solving ability, executive function, and sleep routine in hyperactive and inattentive boys aged 6 to 14.

Super NootrOpa prevents neurochemical alterations in the brain by normalizing the ratio of two NMDAR subunits (NR2A and NR2B) and their downstream mediators (7, 8). Super NootrOpa improves short-term memory and elevates mood by modulating the combined action of serotonergic and cholinergic systems.

Super NootrOpa enhances memory retention via upregulation of Fmr-1 Gene expression. Super NootrOpa acts as an adaptogen by reversing the biochemical changes induced by acute and chronic stressors.

USPs & Application

ECO-FRIENDLY

SUSTAINABLE

WILD HARVESTED

Applications

Gummies, Food, and beverage products

Sachets, Dispersible Powders

Tablets, Hard Gel Capsules,  Soft gel capsules

Features

  • More than 50 years of research
  • IPR protected, Debittered & Taste neutral extract
  • Clinically proved in high quality clinical trials
  • Only nootropic product studied using fMRI in brain
  • Low dose 320 mg/day in adults; 160 mg/day in children
  • Clinically tested efficacy with single dose (Acute benefit at 640 mg dose)
  • Contains not less than 55% Bacosides
  • No known reported drug interactions
  • Formulation friendly

Super NootrOpa

  • Super NootrOpa is scientifically developed, standardized extract, formulated to provide a pleasant taste.
  • Super NootrOpa contains a full spectrum of bioactives.
  • IP Protected
  • 100% Natural & easy to formulate
  • Stable up to 80˚C
  • Stable at acidic pH
  • Low Dose

Scientific research

The Nootropic benefits of Super NootrOpa are demonstrated by 15 published scientific papers consisting of nine randomized human clinical studies, six pre-clinical studies and one meta-analysis conducted across the age groups ranging from 6 to 65 years.

Results

  • Improves Visual attention and multi-tasking ability.
  • Improves Cognitive performance and visual scanning speed.
  • Improved working memory and learning ability.
  • Corrects the Attention-deficit and hyperactivity in children and sleep routine in hyperactive and inattentive boys aged 6 to 14 years.
  • Protects Bain from oxidative damage.
  • Improves learning ability, cognition and elevates mood.
  • Assist in coping with stress.

A potent antioxidant:

Super NootrOpa modulates antioxidant activity and enhances the defense against free radicals induced damage.

Super NootrOpa increases SOD, CAT and GPx activities in the frontal cortex, striatum and hippocampus in rats.

Best in Class for Brain Health

Clinical Benefits of Super NootrOpa

Super NootrOpa

Supported by several human clinical studies

Clinical Study 1

Clinical Study 1

Super NootrOpa 300 mg/day for 12 weeks significantly improved

  • Speed of visual information processing,
  • Learning rate and memory consolidation
  • Anxiety compared to placebo.

Clinical Study 2

Clinical Study 2

Super NootrOpa (300 mg/90 days) significantly

  • Improved Verbal learning,
  • Improved retention of verbal memory
  • Reduced the pro-active interference.

Clinical Study 3

Clinical Study 3

Super NootrOpa (125 mg/twice a day) to subjects (age: 55-70 Y) with age associated memory impairment (AAMI)’ significantly

  • Improved Mental control
  • Improves Visual memory,
  • Enhances learning behavior
  • Increases total memory scores.

Clinical Study 4

Clinical Study 4

Super NootrOpa  (300 mg/day) for 90 days significantly

  • Improved Working Memory performance
  • Improved Visual accuracy.

Clinical Study 5

Clinical Study 5

Single dose (either 320 or 640 mg) of Super NootrOpa showed

  • Moderate improvement in mental performance in subjects (18-56 years)

Clinical Study 6

Clinical Study 6

Single dose of Super NootrOpa (320 & 640 mg) shows

  • Reduced cortisol level
  • Reduced stress
  • Improved alertness
  • Enhanced focus and contentedness.

Clinical Study 7

Clinical Study 7

Super NootrOpa 160 & 320 mg showed significant improvements in

  • Cognitive flexibility (p = .01)
  • Executive functioning by CPRS scale (p = 0.04)

Clinical Study 7

Significant improvements in

  • Interpersonal problems by CDI score (p =0.02)
  • Sleep routine by PSPSI score (p = 0.04)

Clinical Study 8

Clinical study in young children

  • Study: Randomized, double-blind, placebo-controlled parallel study
  • Duration: 4 months
  • No of subjects: 300
  • Super NootrOpa with vitamins and minerals
  • Dose: 130 mg twice daily

Observation:

Spatial working memory significantly improved in school going children (7-12 years)

Clinical Study 8

Clinical Study 8

This was a randomized, double-blind, parallel design trial

  • Spatial working memory “strategy” score showed significant improvement
  • Improved paired associate learning
  • ↓ latency of RVIP (Rapid visual information processing task)

Clinical Study 9

Clinical study in Aged population

  • Study: Randomized, double-blind, placebo-controlled study
  • Duration: 12 weeks
  • No of subjects: 54
  • Dose: 300mg Super NootrOpa once a day

Observation:

Elderly (>65 years) participants improved cognition, decreased anxiety and depression.7

Clinical Study 9

Clinical Study 9

Randomized, double-blind and placebo-controlled study, Significant improvements in

  • Reaction time (RS)0 in the PS-N Patten separation task (PS-N)
  • Immediate word recall accuracy (%)
  • BDNF levels

Preclinical Evidence

Preclinical Evidence

  • Super NootrOpa improved learning and memory (↑Latency Vs. control) in passive avoidance task.
  • Super NootrOpa improved memory (↓Inhibition of AChE activity)
  • Elevated mood (↑ 5HT3A expression, ↑ Increases hippocampal serotonin (p<0.05) & acetylcholine)
  • Modulates NMDA receptors by binding to its subunits NR2A and NR2B.

Preclinical Evidence

  • Super NootOpa enhanced learning and retention of memory (↓ Target latency & ↑ time spent in target quadrant) in Morris water maze (MVM).
  • Super NootOpa acts as neuroprotective- ↑ Fragile X mental retardation protein (FMRP).
  • Improves the neuronal synaptic plasticity (↑ serum BDNF)
  • Enhanced neuronal nitric oxide (nNOS) expression, and nitric oxide (NO) level

Safety

Toxicity

Acute Toxicity:

Acute oral toxicity studies have shown doses up to 5000mg/kg did not show any significant health effects.6

Chronic toxicity:

The B. monnieri extract at a dose of 1500mg/kg for 270 days did not show any abnormalities.6

Mechanism of Action

Mechanism

Mechanism-Cholinergic Pathway

Mechanism

Learning & Memory:

  • Super NootrOpa increases memory formation by modulating the enzyme Tryptophan Hydroxylase (TPH2) and increasing the expression of the serotonin transporter (SERT).1
  • Super Nootropa decreases brain acetyl cholinesterase activity.2
  • Super Nootropa improves learning and memory in young mice and reduces scopolamine-induced amnesia.3

Mechanism
Super NootrOpa